High-performance carbon isotope analysis of LC-separated compounds

Elementar’s LiquiFace is a specialist solution providing high-performance carbon isotope analysis of liquids and separated compounds, with significant benefits in terms of versatility and ease of use.

Compound-specific isotope analysis of aqueous samples by liquid chromatography is highly advantageous for compound classes that are thermolabile, or require derivatisation prior to gas chromatography analysis. Samples such as carbohydrates, amino acids, alcohols, organic acids and peptides make ideal candidates for LC-IRMS, and the technique has been employed to great success in food and biogeochemistry applications.

LiquiFace works as an interface for the LC system to provide quantitative online conversion of organic carbon to CO2, prior to analysis by the IRMS system. Isotopic precision, accuracy and linearity is exceptional due to the highly efficient quantitative conversion of the organic carbon to CO2. This level of performance means that LiquiFace is able to cover a range of sample types with a complete independence upon sample concentration, making the analyst’s life even simpler.

Key features

  • 100% quantitative conversion of organic carbon to CO2 with sodium persulfate oxidation
  • Robust and thermally stable micro-reactor
  • High-efficiency water separation membrane for extraction of dissolved CO2 into helium carrier gas, with no isotopic fractionation
  • Onboard peristaltic pumps that provide easily maintained flows of reaction reagents
  • Connection to any standard LC or IC pumping system using finger-tight peek union connections
  • Inline direct injection valve and 25μl sample loop for performing bulk δ13C isotope analysis of aqueous samples
  • Exceptional tolerance to high oxygen loads