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Isotope ratio mass spectrometer isoprime precisION
isoprime precisION
The most flexible, yet powerful IRMS ever created
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The most flexible isotope ratio mass spectrometer ever created

isoprime precisION is the highest-performing stable isotope ratio mass spectrometer (IRMS) on the market, offering complete flexibility to move in any direction that your research leads. As your research grows into new and novel areas, you will need an instrument that can grow with your research while guaranteeing the highest performance for all analysis types. We have designed isoprime precisION to meet all of these needs.

Analytical power and flexibility is what isoprime precisION is about. With seamless integration of hardware and software delivered in a compact benchtop instrument, it is at the forefront of modern stable isotope ratio mass spectrometry.

Highlights of isoprime precisION

Great flexibility

Complete integration of all inlet systems, including novel inlets

High sensitivity

Analyze the most challenging samples with exceptionally high ion source sensitivity

Small footprint

Almost 50 % smaller than any other commercial stable isotope ratio mass spectrometer

High data quality

Achieve the highest analytical performance with the most precise instrument available


Great Flexibility

Stable isotope ratio mass spectrometry offers unique insight into a broad range of applications, due in part to the high degree of modularity in the available hardware. Our exceptional range of complimentary peripheral inlet systems provides ideal solutions, no matter the application.

We have designed isoprime precisION to seamlessly switch between all of your inlet systems with incredible ease, with the onboard centrION Continuous Flow Interface System automatically handling sample gases delivered by your inlet system. With its automated dilution, switching and standby mode, isoprime precisION delivers simplicity and flexibility to make your workflows more efficient.

High sensitivity

isoprime precisION is the most powerful stable isotope ratio mass spectrometer we have ever created, combining the highest performance with the greatest flexibility to provide the tools to answer the most demanding research questions.

The IRMS provides exceptional ionization efficiency of 1,100 molecules of CO2 per ion in continuous flow mode; when combined with our market-leading inlet peripherals, this results in the highest possible sample sensitivity. With the Advanced Purge and Trap (APT) technology offered by our range of elemental analyzers, the micro volume furnace design in our GC systemand the unique UltiTrap technology offered by the iso FLOWstable isotope handling platform, you can be sure that isoprime precisION will help you to advance your research goals.

Small footprint

isoprime precisION packs a lot of technology into a very small footprint. We understand that more and more laboratories are increasingly congested, with many different types of analytical instrumentation putting space at a precious premium; by contrast, isoprime precisION is a high-performance, full-form stable isotope ratio mass spectrometer delivered in an incredibly compact benchtop form factor.

High-quality data

The ionOS® software capabilities of isoprime precisION allow it to provide the very highest data quality for any research sphere.

Data quality is generally dependent on a number of factors, including sample preparation, analytical methodology and data interpretation. Thanks to ionOS® and its Method Workflow Designer, standard methodologies can be fine-tuned, while completely bespoke methods can also be created for novel inlet systems, allowing all of these factors to be accounted for at all times.

ionOS® also makes examining data quality very simple, with its instant statistical analysis and automatic multipoint multi-isotope calibrations ensuring that samples are analyzed consistently and robustly.

Product details

Isotope ratio mass spectrometer isoprime precisION

isoprime precisION IRMS

isoprime precisION forms the core of your system, a starting point from which to grow your research. Maximize the possible analyses with your system by choosing any combination of inlet systems, and automatically switch between them using the centrION Continuous Flow Interface System, which is incorporated into the instrument.

Novel Inlet Control Module

Perhaps your research topic demands something different? Then you can interface isoprime precisION with your bespoke experimental system with the revolutionary Novel Inlet Control Module (NICM), which offers substantial control of additional I/O with the elegant Method Workflow Designer. Adding multi-collector arrays with bespoke amplification resistor configurations will drive your experiment even further.

Planning proactively for possible future research requirements is simple when you have an instrument that performs to the very highest levels. isoprime precisION offers the highest gas ionization performance and mass resolution, all in the most compact footprint possible.

ionOS® IRMS software

Our ionOS® stable isotope software works in concert with isoprime precisION and centrION to provide an unrivalled level of intelligent control. Designed completely from the ground up for stable isotope analysis, ionOS® is the most sophisticated yet simple software ever created for this market. Its clean user interface belies the level of sophistication within, giving users unrivalled capabilities to generate exceptional data with ease.

A powerful yet simple tool, ionOS® delivers a world of opportunity for your laboratory. With complete control of the hardware and simple programming with the Method Workflow Designer, you can continue expanding your research horizons over time.

Find out more about ionOS® here

Isotope ratio mass spectrometry software ionOS

We offer a broad portfolio of peripheral inlet systems designed specifically for stable isotope analysis. The choice of inlet system depends on your experimental requirements, but whichever inlet you choose, you can be sure that your samples are handled exactly and faithfully with absolutely no isotope fractionation. Complete automation and switching makes isoprime precisION the most dynamic and flexible stable isotope mass spectrometer ever created.

Elemental analyzer vario PYRO cube for EA-IRMS

Elemental analysis

Conversion of bulk organics and inorganics in solid and liquid sample matrices into pure gases, prior to isotope analysis.

GC5 with Agilent 7890B gas chromatograph


Column separation of complex organic mixtures using GC and LC techniques and converted into sample gases in real time.

iso FLOW headspace analyzer coupled to an isoprime precisION IRMS system


Preparation, separation and analysis of air, breath, liquid and carbonate samples, prepared into septum-sealed vials.

Isotope ratio mass spectrometer isoprime precisION with dual inlet analyzer iso DUAL INLET

Gas analysis

Concentration and separation of various gaseous sample types prior to isotope analysis.

  • 100 V amplification for large dynamic-range samples with auto resistor switching 

  • Simultaneous measurement of up to 10 ion beams across a ± 25 % mass range for multi-collector experiments 

  • Improved gas ionization performance of 1,100 molecules/ion (CO2 in CF mode) 

  • Improved mass resolution of 110 m/Δm (at 10 % valley separation) 

  • ionOS® Method Workflow Designer for developing bespoke control of your instrument 

  • Handle up to six monitoring gases and five inlets with centrION Continuous Flow Interface System 

  • Vacuum-grade stainless steel analyzer for the highest vacuum performance, with optional bakeout 

  • Automatic control of every aspect of the hardware with ionOS® 

  • Bespoke DAC dual-resistor configurations for non-standard isotopomer distributions 

  • Instant instrument status recognition with color LED warnings 


Product flyer
Flyer isoprime precisION
Fingerprint and weathering characteristics of crude oils after an oil spill
High precision δ13C and δ18O apatite carbonate measurements
Palaeoclimate inferred from earthworms calcite granules δ18O analyses
δ18O analyses of fruit juice samples using iso FLOW
Calibration of isotope ratio analyses using international reference standards
Considerations of dynamic range in stable isotope analysis Part 1: intrinsic isotope abundance
Considerations of dynamic range instable isotope analysis Part 2: elemental abundance
High precision and accuracy analyses of carbon and nitrogen isotope ratios
High precision and accuracy GC-C-IRMS analyses of a certified reference mixture
High precision δ13C measurements over a large concentration range
High sensitivity δ15N analyses
High sensitivity δ34S analyses in samples with low sulfur abundance
Oxygen isotope measurements using high temperature pyrolysis
Novel Inlet Controle Module


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