It was the beginning of industrial-scale production of devices for instrumental analytics, a sector that now serves a wide range of applications and methods and monitors the very foundations of modern life. Over the course of decades, the areas of application for elemental analyzers have changed considerably and have seen constant expansion.
At the same time, the demands placed on elemental analysis have become ever more stringent. Significantly lower sample weights were required in the fields of biochemistry, physiology or forensics in particular. Fritz Pregl (1869–1930), a professor for medical chemistry in Innsbruck and Graz, was the first to successfully analyze carbon, hydrogen and nitrogen (CHN) in a sample of < 1 mg body fluid; this success was due to his outstanding experimental skills and miniaturization.