Net peptide content analysis without compromise

In the past, you had to compromise when determining the net peptide content (NPC) of lyophilized powder. Now the highly sensitive carbon and nitrogen analyzer, UNICUBE® trace, links it all:

Cost-per-analysis of 0.55 €
Sample prep of 3 min only
Sample size of less than 1 mg
GMP compliance
Highest accuracy and precision
Training for your staff

Need to measure additional elements and/or samples?

NPC can be determined just as easily with the “UNICUBE®”, which can measure C, H, N, S, O* and Cl*. In addition to peptides, both instruments can analyze a wide variety of samples such as fluorinated pharmaceutical compounds, chromatography resins, liquid fuels, and inhomogeneous soils.

*optional configuration

Delve into real data

The peptidic material is the only source of nitrogen in the lyophilized powder. Therefore, the NPC can be calculated once the absolute amount of nitrogen in the powder has been determined. 20 µg of nitrogen suffice to produce high-quality NPC data via the UNICUBE® trace. Explore how the nitrogen results obtained via the UNICUBE® trace compare to Bachem's certified values.

Did you know? NPC analysis via the UNICUBE® trace fully complies with USP <1057> method 7 procedure 2 and Ph. Eur. monograph 01/2008:02533 method 7B on total protein measurement procedures.

Blue containers with standards from Bachem for net peptide content analysis

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NPC analysis made easy

NPC analysis via the UNICUBE or UNICUBE trace only requires 3 minutes of manual sample preparation and as little as 5 minutes for the subsequent fully automated analysis. See how this compares to amino acid analysis:

UNICUBE or UNICUBE trace	Amino Acid Analysis
weigh peptide powder into tin foil place sample into autosampler get results after a five minute, fully-automated analysis	liquid-phase hydrolysis of the peptide via boiling in 6N HCl pre-column derivatization of the free amino acids separation and detection of amino acids by RP-HPLC

GMP-compliant net peptide determination at CUP Laboratorien Dr. Freitag GmbH

CUP Laboratorien Dr. Freitag GmbH offers contract analysis for customers in the pharmaceutical and medical technology sectors. Managing Director Dr. Dirk Freitag-Stechl and his team explain which special features have to be considered in the GMP environment and how the elemental analyzer UNICUBE® is used for GMP-compliant determination of the net peptide content.

A lab technician stands beside an elemental analyzer for net peptide content analysis

Red front page of a guide, containing GMP relevant information

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Your contractual consideration for the free provision of the download is the subscription to our personalized newsletter. By clicking on the “download now” button, you therefore declare your acceptance of the receipt of personalized newsletters by e-mail by Elementar Analysensysteme GmbH and its group companiesas well as the evaluation of your user behavior in this regard and - if available - the merging of this data with your data in our customer database.

In order to receive newsletters from our group companies, it is necessary to transfer your above-mentioned personal data to these companies. We point out that these are partly located in so-called unsafe third countries outside the EU/EEA, in which no adequate level of data protection (e.g. by adequacy decision of the EU, Art. 45 GDPR) is guaranteed. In these countries, you may not be able to enforce your rights as a data subject, or only to a limited extent. In addition, it is possible that local government agencies access your data to a disproportionate extent. The data transfer is based on Art. 49 para. 1 lit. b) GDPR.

You are aware that the subscription to our personalized newsletter represents the contractual consideration that you provide for the free provision of the download. You can unsubscribe from the newsletter at any time with effect for the future. You can object to the future use of your data for advertising purposes at any time. For further information, please refer to our privacy policy.

We've got you covered

To ensure full GMP compliance, we offer:

analyzer qualifications (IQ/OQ/PQ) executed by trained service engineers
21 CFR part 11 software option
reference materials with %CHNOS values traceable to NIST standards

To train staff quickly, we provide:

online and in-person analyzer trainings
instructional videos (e.g. sample preparation, routine maintenance tasks)
support from our application lab personnel

For more information on our GMP compliant portfolio of organic elemental analyzers and TOC analyzers, follow the link to our GMP Service overview

CLICK HERE

Get in touch with us for more information

You would like to have more information? We will be happy to answer your questions about the UNICUBE®, the UNICUBE trace® and the net peptide determination. Let us know how we can support you.

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